Potent furin inhibitors for the treatment of infectious diseases
نویسندگان
چکیده
Background: Furin and furin-like proprotein convertases are involved in disease related processes and emerged as potential drug targets. Results: The incorporation of basic acyl residues in P5 position provides highly potent inhibitors of furin, PC1/3, PC4, PACE4, and PC5/6. Conclusion: These inhibitors could be potential drugs for the treatment of infectious diseases. Significance: Development of the most potent synthetic inhibitors of furin-like proprotein convertases.
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